Hodgkin's lymphoma‐associated vanishing bile duct syndrome successfully treated with radiation as a bridge to chemotherapy

Abstract Vanishing bile duct syndrome is a paraneoplastic manifestation of Hodgkin's lymphoma that often proves fatal. Treatment the underlying with chemotherapy priority, and liver dysfunction frequently prohibitive. A 27‐year‐old woman presented severe cholestatic hepatitis was diagnosed as vanishing on biopsy. Chest imaging showed mediastinal supraclavicular lymphadenopathy lymphoma. She administered involved‐site radiation (3960 cGy), yielding partial remission marked improvement in function. Subsequently, standard achieved complete remission. total 19 months thereafter, patient normal We conclude tumor‐directed radiotherapy can be used bridge to curative lymphoma‐associated syndrome. (VBDS) rare fatal presentation Hodgkin (HL) In HL above diaphragm VBDS, tumor resulted cytoreduction improved function Curative‐intent subsequently initiated led resolution injury HL‐associated RT